A convergent ring-closing metathesis approach to carbohydrate-based macrolides with potential antibiotic activity

被引：35

作者：

Blom, P

Ruttens, B

Van Hoof, S

Hubrecht, I

Van der Eycken, J

Sas, B

Van hemel, J

Vandenkerckhove, J

机构：

[1] Univ Ghent, Dept Organ Chem, Lab Organ & Bioorgan Synth, B-9000 Ghent, Belgium

[2] Kemin Pharma Europe, B-2200 Herentals, Belgium

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 24期

关键词：

D O I：

10.1021/jo051021k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient convergent approach has been developed for the construction of novel, non-natural, carbohydrate-based macrolides. The key step in the synthesis is the formation of the macrocyclic ring via a ring-closing metathesis reaction. The obtained macrolide analogues have been screened for biological activity against, Gram-positive and Gram-negative bacteria, including resistant strains, yeasts, and molds.

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页码：10109 / 10112

页数：4

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