Human immunodeficiency virus-related microbial translocation and progression of hepatitis C

被引：223

作者：

Balagopal, Ashwin ^{[1
]}

Philp, Frances H. ^{[1
]}

Astemborski, Jacquie ^{[1
,2
]}

Block, Timothy M. ^{[3
,4
]}

Mehta, Anand ^{[3
,4
]}

Long, Ronald ^{[3
,4
]}

Kirk, Gregory D. ^{[1
,2
]}

Mehta, Shruti H. ^{[1
,2
]}

Cox, Andrea L. ^{[1
]}

Thomas, David L. ^{[1
,2
]}

Ray, Stuart C. ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Med, Div Infect Dis, Viral Hepatitis Ctr, Baltimore, MD 21205 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Drexel Coll Med, Hepatitis B Fdn, Doylestown, PA USA

[4] Drexel Coll Med, Drexel Inst Biotechnol & Virol Res, Doylestown, PA USA

来源：

GASTROENTEROLOGY | 2008年 / 135卷 / 01期

关键词：

D O I：

10.1053/j.gastro.2008.03.022

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background&Aims: Human immunodeficiency virus (HIV)-l infection has been associated with enhanced microbial translocation, and microbial translocation is a mechanism through which alcohol and some enteric conditions cause liver disease. We hypothesized that HIV promotes liver disease by enhancing microbial translocation. Methods: We studied human cohorts in which hepatitis C virus (HCV) and HIV outcomes were carefully characterized. Results: HIV-related CD4(+) lymphocyte depletion was strongly associated with microbial translocation as indicated by elevated levels of circulating hpopolysaccharide (LPS), LPS-binding protein, soluble CD14, and fucose-binding lectin (AAL) reactive to immunoglobulin G specific for the a-galactose epitope and suppressed levels of endotoxin core antibodies (EndoCAb IgM) in HIV-infected subjects compared with the same persons before they had HIV infection and compared with HIV-uninfected subjects. The same measures of microbial translocation were strongly associated with HCV-related liver disease progression (cirrhosis), eg, LPS, odds ratio, 19.0 (P =.002); AAL, odds ratio, 27.8 (P <.0001); in addition, levels of LPS were elevated prior to recognition of cirrhosis. Conclusions: Microbial translocation may be a fundamental mechanism through which HIV accelerates progression of chronic liver disease.

引用

页码：226 / 233

页数：8

共 45 条

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ADACHI Y, 1994, HEPATOLOGY, V20, P453, DOI 10.1002/hep.1840200227

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