The inclusion compound of a new ionizable derivative of β-cyclodextrin with ferrocenium drug

A new beta -cyclodextrin (beta -CD) derivative, mono(6-deoxy-6-(2-butenedinitrile-2,3-dimercapto sodium salt)]-beta- CD (6-mnt-beta -CD), and its inclusion compound with a ferrocenium drug, have been prepared and characterized by. IR, UV, C-13-NMR spectroscopy, and mass spectrometry, elemental analysis, thermogravimetry, and cyclic voltammetry (CV). The interplay between the side-arm anion of beta -CD and the ferrocenium (guest) in the inclusion compound 6-mnt-beta -CD-/Fc(+) has been investigated by C-13-NMR, UV, IR, and thermogravimetric methods. Charge transfer from the anion to the cation in 6-mnt-beta -CD-/Fc(+) was then experimentally identified. The interaction between the guest and the host with side-arm in 6-mnt-beta -CD-/Fc(+) resulted in smaller positive potential shifts compared to that in the inclusion compound [beta -CD/Fc(+)]BF4-.