Life events, perceived stress and antibody response to influenza vaccination in young, healthy adults

被引：39

作者：

Burns, VE ^{[1
]}

Carroll, D

Drayson, M

Whitham, M

Ring, C

机构：

[1] Univ Birmingham, Sch Sport & Exercise Sci, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Div Immun & Infect, Birmingham B15 2TT, W Midlands, England

[3] Univ Coll N Wales, Sch Sport Hlth & Exercise Sci, Bangor, Gwynedd, Wales

来源：

JOURNAL OF PSYCHOSOMATIC RESEARCH | 2003年 / 55卷 / 06期

关键词：

psychoneuroimmunology; psychosocial stress; vaccination;

D O I：

10.1016/S0022-3999(03)00073-4

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect. Methods: Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective. Results: At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected. Conclusion: Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：569 / 572

页数：4

共 24 条

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