Mechanisms of force generation and transmission by myofibroblasts

被引：323

作者：

Hinz, B

Gabbiani, G

机构：

[1] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol, Lab Cell Biophys, CH-1015 Lausanne, Switzerland

[2] Univ Geneva, CMU, Dept Pathol, CH-1211 Geneva 4, Switzerland

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2003年 / 14卷 / 05期

关键词：

D O I：

10.1016/j.copbio.2003.08.006

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The myofibroblast has been shown to have a key role in tissue reconstruction after injury and pathological changes characterized by fibrosis. Force generation by the myofibroblast depends on the isometric contraction of stress fibers containing alpha-smooth muscle actin, and is mediated through Rho/Rho-kinase. The force is transmitted by vinculin and tensin-containing 'supermature' focal adhesions, which connect stress fibers with the extracellular matrix. Force production and transmission by the myofibroblast are modulated by the coordinated action of cytokines, extracellular matrix components and mechanical tension. Regulation of these phenomena will be important for therapeutic strategies aimed at influencing fibrocontractive diseases.

引用

页码：538 / 546

页数：9

共 74 条

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