Screening method for the analysis of antiviral drugs in poultry tissues using zwitterionic hydrophilic interaction liquid chromatography/tandem mass spectrometry

被引：41

作者：

Chan, D. ^{[1
]}

Tarbin, J. ^{[1
]}

Sharman, M. ^{[1
]}

Carson, M. ^{[2
]}

Smith, M. ^{[2
]}

Smith, S. ^{[2
]}

机构：

[1] Food & Environm Res Agcy, York YO41 1LZ, N Yorkshire, England

[2] US FDA, Div Residue Chem, Off Res, Ctr Vet Med, Laurel, MD 20708 USA

来源：

ANALYTICA CHIMICA ACTA | 2011年 / 700卷 / 1-2期

关键词：

Antiviral; Amantadine; Acyclovir; Ganciclovir; Imiquimod; Oseltamivir; Oseltamivir carboxylate; Rimantadine; Poultry; Zanamivir; OSELTAMIVIR; AMANTADINE; PLASMA; RAT;

D O I：

10.1016/j.aca.2010.11.015

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

A screening method for the analysis of seven anti-viral drugs in poultry tissue has been developed. These include anti-influenza drugs (amantadine, rimantadine, zanamivir and oseltamivir and its carboxylate metabolite), anti-herpes drugs (acyclovir and ganciclovir) and an immunomodulator (imiquimod). Poultry tissue was extracted in acetonitrile:water:acetic acid. After sample purification, using a strong cation exchange column, the eluate was split into two fractions. The first portion was dissolved in methanol:water and the second in acetonitrile:methanol:water. Both fractions were analysed on a zwitterionic hydrophilic interaction liquid chromatography column coupled to a triple quadrupole mass spectrometer. The screening method was successfully validated according to Commission Decision 2002/657/EC in three different laboratories with CC beta concentrations of <= 10 mu g kg(-1). Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.

引用

页码：194 / 200

页数：7

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