Neuroprotection during cardiac surgery

被引：23

作者：

Grocott, Hilary P. ^{[1
]}

Yoshitani, Kenji ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA

来源：

JOURNAL OF ANESTHESIA | 2007年 / 21卷 / 03期

关键词：

cardiac surgery; cardiopulmonary bypass; brain; neuroprotection;

D O I：

10.1007/s00540-007-0514-1

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

Cerebral injury following cardiac surgery continues to be a significant source of morbidity and mortality after cardiac surgery. A spectrum of injuries ranging from subtle neurocognitive dysfunction to fatal strokes are caused by a complex series of multifactorial mechanisms. Protecting the brain from these injuries has focused on intervening on each of the various etiologic factors. Although numerous studies have focused on a pharmacologic solution, more success has been found with nonpharmacologic strategies, including optimal temperature management and reducing emboli generation.

引用

页码：367 / 377

页数：11

共 117 条

[1]

Effect of off-pump coronary artery bypass surgery on clinical, angiographic, neurocognitive, and quality of life outcomes: randomised controlled trial [J].

Al-Ruzzeh, Sharif ;

George, Shane ;

Bustami, Mahmoud ;

Wray, Jo ;

Ilsley, Charles ;

Athanasiou, Thanos ;

Amrani, Mohamed .

BMJ-BRITISH MEDICAL JOURNAL, 2006, 332 (7554) :1365-1368

[2]

Postcardiac surgery complications: Association of acute renal dysfunction and atrial fibrillation [J].

Albahrani, MJ ;

Swaminathan, M ;

Phillips-Bute, B ;

Smith, PK ;

Newman, MF ;

Mathew, JP ;

Stafford-Smith, M .

ANESTHESIA AND ANALGESIA, 2003, 96 (03) :637-643

[3]

Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits [J].

Aldea, GS ;

Soltow, LO ;

Chandler, WL ;

Triggs, CM ;

Vocelka, CR ;

Crockett, GI ;

Shin, YT ;

Curtis, WE ;

Verrier, ED .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2002, 123 (04) :742-755

[4]

Neuroprotection is associated with β-adrenergic receptor antagonists during cardiac surgery:: Evidence from 2,575 patients [J].

Amory, DW ;

Grigore, A ;

Amory, JK ;

Gerhardt, MA ;

White, WD ;

Smith, PK ;

Schwinn, DA ;

Reves, JG ;

Newman, MF .

JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2002, 16 (03) :270-277

[5]

[Anonymous], 1994, Lancet, V343, P559

[6]

Neuroprotection of the brain during cardiopulmonary bypass - A randomized trial of remacemide during coronary artery bypass in 171 patients [J].

Arrowsmith, JE ;

Harrison, MJG ;

Newman, SP ;

Stygall, J ;

Timberlake, N ;

Pugsley, WB .

STROKE, 1998, 29 (11) :2357-2362

[7]

Baudet B, 1999, ANESTH ANALG, V88, pU74

[8]

EFFECTS OF ISOFLURANE AND HYPOTHERMIA ON GLUTAMATE RECEPTOR-MEDIATED CALCIUM INFLUX IN BRAIN-SLICES [J].

BICKLER, PE ;

BUCK, LT ;

HANSEN, BM .

ANESTHESIOLOGY, 1994, 81 (06) :1461-1469

[9]

INSENSITIVITY OF IMPLICIT MEMORY TO ANESTHESIA METHODS [J].

BLOCK, RI ;

GHONEIM, MM .

ANESTHESIOLOGY, 1994, 81 (02) :516-516

[10]

The effect of methylprednisolone treatment on the cardiopulmonary bypass-induced systemic inflammatory response [J].

Bourbon, A ;

Vionnet, M ;

Leprince, P ;

Vaissier, E ;

Copeland, J ;

McDonagh, P ;

Debré, P ;

Gandjbakhch, I .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2004, 26 (05) :932-938

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