Glycosidation of solid-supported glycosyl donors tethered by a trialkylsilane linker

被引：37

作者：

Doi, T

Sugiki, M

Yamada, H

Takahashi, T

Porco, JA

机构：

[1] Tokyo Inst Technol, Dept Chem Engn, Meguro Ku, Tokyo 152, Japan

[2] Argonaut Technol, San Carlos, CA 94070 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 11期

关键词：

glycosidation; solid-phase synthesis; thioglycosides; resins;

D O I：

10.1016/S0040-4039(99)00133-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Glycosidation of silicon-connected glycosyl donors on polystyrene resin is described Thiophenyl glycoside 2a and glucopyranosyl fluoride 2 b reacted with glycosyl acceptor 3 (R-2 = Bn) to give disaccharide 4a in 96% and 70% yields, respectively. Glycosidation of thiophenyl glucoside 2a (R-1 =Bn or Bz) with glycosyl acceptor 3 (R-2 =Bn or Ac) yielded 4a-4c in satisfactory yields and 4d in moderate yield. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2141 / 2144

页数：4

共 26 条

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BELORIZKY N, 1972, B SOC CHIM FR, P4749

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