Determining the Enantioselectivity of Chiral Catalysts by Mass Spectrometric Screening of Their Racemic Forms

被引：51

作者：

Ebner, Christian ^{[1
]}

Mueller, Constanze A. ^{[1
]}

Markert, Christian ^{[1
]}

Pfaltz, Andreas ^{[1
]}

机构：

[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 13期

基金：

瑞士国家科学基金会;

关键词：

HOMOGENEOUS CATALYSIS; COMPLEXES; LIGANDS; CHEMISTRY; MIXTURES;

D O I：

10.1021/ja111700e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselectivity of a chiral catalyst can be determined from its racemic form by mass spectrometric screening of a nonequal mixture of two mass-labeled quasienantiomeric substrates. The presented method opens up new possibilities for evaluating catalyst structures that are not readily available in enantiomerically pure form.

引用

收藏

页码：4710 / 4713

页数：4

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