Epigenetic control of adult stem cell function

被引：180

作者：

Avgustinova, Alexandra ^{[1
]}

Benitah, Salvador Aznar ^{[1
,2
]}

机构：

[1] Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain

[2] Catalan Inst Res & Adv Studies, ICREA, Barcelona 08010, Spain

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2016年 / 17卷 / 10期

基金：

欧洲研究理事会;

关键词：

REPRESSIVE COMPLEX 2; DNA METHYLATION PATTERNS; POLYCOMB-GROUP GENES; ZINC-FINGER PROTEIN; HEMATOPOIETIC STEM; SKELETAL-MUSCLE; SELF-RENEWAL; HAIR FOLLICLE; MAMMARY-GLAND; HISTONE H3;

D O I：

10.1038/nrm.2016.76

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Mammalian embryonic development is a tightly regulated process that, from a single zygote, produces a large number of cell types with hugely divergent functions. Distinct cellular differentiation programmes are facilitated by tight transcriptional and epigenetic regulation. However, the contribution of epigenetic regulation to tissue homeostasis after the completion of development is less well understood. In this Review, we explore the effects of epigenetic dysregulation on adult stem cell function. We conclude that, depending on the tissue type and the epigenetic regulator affected, the consequences range from negligible to stem cell malfunction and disruption of tissue homeostasis, which may predispose to diseases such as cancer.

引用

页码：643 / 658

页数：16

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