BRCA1 mutations and phenotype

被引：9

作者：

Grade, K ^{[1
]}

Hoffken, K ^{[1
]}

Kath, R ^{[1
]}

Nothnagel, A ^{[1
]}

Bender, E ^{[1
]}

Scherneck, S ^{[1
]}

机构：

[1] UNIV JENA,INNERE MED KLIN,D-07740 JENA,GERMANY

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1997年 / 123卷 / 01期

关键词：

BRCA1; mutations; phenotype; CANCER SUSCEPTIBILITY GENE; OVARIAN-CANCER; BREAST-CANCER; FAMILIES;

D O I：

10.1007/BF01212618

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

More than 100 mutations have been described for the breast-cancer-susceptibility gene BRCA1. The paper describes phenotypical aspects of three selected mutations located at the beginning, in the middle, and at the end of the gene. A remarkable decrease of the age of diagnosis of the mammary carcinoma is observed with increasing length of the putative gene product, combined with greater severity of the disease.

引用

页码：69 / 70

页数：2

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