Sequence and polymorphism analysis of the murine gene encoding histidyl-tRNA synthetase

被引：7

作者：

Blechynden, LM ^{[1
]}

Lawson, CM ^{[1
]}

Garlepp, MJ ^{[1
]}

机构：

[1] QUEEN ELIZABETH II MED CTR,AUSTRALIAN NEUROMUSCULAR RES INST,NEDLANDS,WA 6009,AUSTRALIA

来源：

GENE | 1996年 / 178卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

aminoacyl-tRNA synthetase; nucleotide sequence; polymyositis; single-stranded conformational polymorphism; laboratory mouse; Mus spretus;

D O I：

10.1016/0378-1119(96)00358-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The murine histidyl-tRNA synthetase-encoding gene (MMHRS) coding region has been cloned and sequenced. The 1527-bp transcript shows a strikingly similar structural organization to that of its human counterpart, particularly within the three class II aminoacyl-tRNA synthetase structural motifs and the two histidyl-tRNA synthetase signature regions. It is predicted, as in humans, to have a coiled-coil alpha-helical structure that is characteristic of many autoantigens. MMHRS shows some degree of polymorphism at both the DNA and amino-acid levels, although its sequence is well conserved amongst the commonly used laboratory mouse strains.

引用

页码：151 / 156

页数：6

共 21 条

[1] ANTI-JO-1 ANTIBODY - A MARKER FOR MYOSITIS WITH INTERSTITIAL LUNG-DISEASE [J].

BERNSTEIN, RM ;

MORGAN, SH ;

CHAPMAN, J ;

BUNN, CC ;

MATHEWS, MB ;

TURNERWARWICK, M ;

HUGHES, GRV .

BRITISH MEDICAL JOURNAL, 1984, 289 (6438) :151-152

[2] AN ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR THE DETECTION AND QUANTITATION OF ANTI-JO-1 ANTIBODY IN HUMAN-SERUM [J].

BISWAS, T ;

MILLER, FW ;

TAKAGAKI, Y ;

PLOTZ, PH .

JOURNAL OF IMMUNOLOGICAL METHODS, 1987, 98 (02) :243-248

[3] PLASTICITY OF THE DIFFERENTIATED STATE [J].

BLAU, HM ;

PAVLATH, GK ;

HARDEMAN, EC ;

CHIU, CP ;

SILBERSTEIN, L ;

WEBSTER, SG ;

MILLER, SC ;

WEBSTER, C .

SCIENCE, 1985, 230 (4727) :758-766

[4]

BONHOMME F, 1986, CURR TOP MICROBIOL, V127, P19

[5] COGNITION, MECHANISM, AND EVOLUTIONARY RELATIONSHIPS IN AMINOACYL-TRANSFER RNA-SYNTHETASES [J].

CARTER, CW .

ANNUAL REVIEW OF BIOCHEMISTRY, 1993, 62 :715-748

[6] SEQUENCE, STRUCTURAL AND EVOLUTIONARY RELATIONSHIPS BETWEEN CLASS-2 AMINOACYL-TRANSFER RNA-SYNTHETASES [J].

CUSACK, S ;

HARTLEIN, M ;

LEBERMAN, R .

NUCLEIC ACIDS RESEARCH, 1991, 19 (13) :3489-3498

[7] THE AMINOACYL-TRANSFER RNA-SYNTHETASE FAMILY - MODULES AT WORK [J].

DELARUE, M ;

MORAS, D .

BIOESSAYS, 1993, 15 (10) :675-687

[8] LONG CHARGE-RICH ALPHA-HELICES IN SYSTEMIC AUTOANTIGENS [J].

DOHLMAN, JG ;

LUPAS, A ;

CARSON, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 195 (02) :686-696

[9] PARTITION OF TRANSFER-RNA SYNTHETASES INTO 2 CLASSES BASED ON MUTUALLY EXCLUSIVE SETS OF SEQUENCE MOTIFS [J].

ERIANI, G ;

DELARUE, M ;

POCH, O ;

GANGLOFF, J ;

MORAS, D .

NATURE, 1990, 347 (6289) :203-206

[10] INTERFERON INDUCIBILITY OF MAMMALIAN TRYPTOPHANYL-TRANSFER RNA-SYNTHETASE - NEW PERSPECTIVES [J].

KISSELEV, L ;

FROLOVA, L ;

HAENNI, AL .

TRENDS IN BIOCHEMICAL SCIENCES, 1993, 18 (07) :263-267

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