Immune microenvironmental shift along human colorectal adenoma-carcinoma sequence: is it relevant to tumor development, biomarkers and biotherapeutic targets?

被引:27
作者
Cui, Guanglin [1 ,2 ,3 ]
Shi, Yingpeng [1 ]
Cui, Jing [1 ]
Tang, Fuai [1 ]
Florholmen, Jon [2 ,3 ]
机构
[1] Zhengzhou Univ, Affiliated Hosp 2, Dept Gastroenterol, Zhengzhou 455000, Peoples R China
[2] Univ Hosp N Norway, Res Grp Gastroenterol & Nutr, Tromso, Norway
[3] Univ Trosmo, Inst Clin Med, Tromso, Norway
关键词
adenoma; carcinogenesis; colorectum; immunosuppressive; immunosurveillance; ENDOTHELIAL GROWTH-FACTOR; REGULATORY T-CELLS; HUMAN COLON-CARCINOMA; C-REACTIVE PROTEIN; CANCER PATIENTS; DENDRITIC CELLS; PROGNOSTIC-SIGNIFICANCE; INFILTRATING LYMPHOCYTES; IMPAIRED INTERLEUKIN-12; INFLAMMATORY CYTOKINES;
D O I
10.3109/00365521.2011.648950
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Human colorectal carcinoma (CRC) is one of the leading cancers. Every year, the WHO estimates a total of 945,000 new CRC cases, with 492,000 deaths worldwide. Most CRCs arise from the main premalignant lesion, colorectal adenomas, and the progression of colorectal adenoma to CRCs may take a long-term time course. The development of human CRCs is not only determined by the adenomatous cells, but also by the interaction between adenomatous cells and host immune environment. In response to tumor initiation or invasion, many inflammatory cells and components will be inevitably activated and form an inflammatory microenvironment surrounding the CRC tumors. Accumulative evidence has revealed that inflammatory response plays a key role in the development of human CRCs by implicating in many aspects including in determining the microenvironmental immune function shift from immunosurveillance to immunosuppression and significantly influences the progression of precancerous lesions to cancers. In this review, the functional changes of immune microenvironment from precancerous stage (adenoma) to cancer stage are summarized, and their potential as predictive biomarkers and biotherapeutic significance in preventing the development of CRCs are discussed.
引用
收藏
页码:367 / 377
页数:11
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