Differential expression of insulin receptor tyrosine kinase inhibitor (fetuin) gene in a model of diet-induced obesity

被引：60

作者：

Lin, X ^{[1
]}

Braymer, HD ^{[1
]}

Bray, GA ^{[1
]}

York, DA ^{[1
]}

机构：

[1] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA

来源：

LIFE SCIENCES | 1998年 / 63卷 / 02期

关键词：

dietary fat; fetuin; obesity; differential display;

D O I：

10.1016/S0024-3205(98)00250-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The Differential Display technique has been used to identify differences in mRNA expression in adipose tissue after the introduction of a high fat diet to two strains of rat (OM and S5B/PI) that differ in their susceptibility to develop obesity on this diet. The insulin receptor tyrosine kinase inhibitor protein (fetuin) was shown to be differentially expressed in OM but not S5B/PI rats. This circulating protein may play a role in the development of peripheral insulin resistance associated with high fat diets.

引用

页码：145 / 153

页数：9

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