Effects of Thymoquinone on radiation enteritis in mice

被引：28

作者：

Hou, Qinlian ^{[1
,2
]}

Liu, Linlin ^{[3
]}

Dong, Yinping ^{[1
,2
]}

Wu, Jing ^{[1
,2
]}

Du, Liqing ^{[1
,2
]}

Dong, Hui ^{[1
,2
]}

Li, Deguan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Radiat Med, Tianjin 300192, Peoples R China

[2] Peking Union Med Coll, Tianjin Key Lab Radiat Med & Mol Nucl Med, Tianjin 300192, Peoples R China

[3] Tianjin Hosp Itcwm Nankai Hosp, Dept Prediatr, Tianjin 300100, Peoples R China

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

基金：

中国国家自然科学基金;

关键词：

INTESTINAL EPITHELIUM; APOPTOSIS; CELLS;

D O I：

10.1038/s41598-018-33214-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Radiation enteritis is an old but emerging question induced by the application of radiation. However, no effective drugs for radiation enteritis in clinic. In this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation. After exposure to irradiation, TQ-treated improved the irradiated mice survival rate, ameliorated intestinal injury and increased the numbers of intestinal crypts. Furthermore, Lgr5(+) ISCs and their daughter cells, including Vil1(+) enterocytes, Ki67(+) cells and lysozyme(+) Paneth cells, were all significantly increased with TQ treatment. In addition, P53, gamma H2AX, caspase8, caspase9 and caspase3 expression were all reduced by TQ. Our data showed that TQ modulated DNA damages and decreased the apoptosis in the small intestine. TQ might be used for radiation enteritis treatment.

引用

页码：1 / 7

页数：7

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