2011: the immune hallmarks of cancer

被引：251

作者：

Cavallo, Federica ^{[1
]}

De Giovanni, Carla ^{[2
]}

Nanni, Patrizia ^{[2
]}

Forni, Guido ^{[1
]}

Lollini, Pier-Luigi ^{[3
]}

机构：

[1] Univ Turin, Ctr Mol Biotechnol, Dept Clin & Biol Sci, I-10126 Turin, Italy

[2] Univ Bologna, Alma Mater Studiorum, Dept Expt Pathol, Canc Res Sect, I-40126 Bologna, Italy

[3] Univ Bologna, Alma Mater Studiorum, Dept Hematol & Oncol Sci L&A Seragnoli, Canc Res Sect, I-40126 Bologna, Italy

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2011年 / 60卷 / 03期

关键词：

Cancer; Inflammation; Immune surveillance; Immune suppression; Oncoantigens; Tumor vaccine; Antitumor antibodies; REGULATORY T-CELLS; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; IFN-GAMMA; MAMMARY-CARCINOMA; DNA VACCINATION; DOWN-REGULATION; GP350; VACCINE; INFLAMMATION; PROGRESSION;

D O I：

10.1007/s00262-010-0968-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ten years after the publication of the position paper "The hallmarks of cancer" (Hanahan and Weinberg Cell 100:57-70, 2000), it has become increasingly clear that mutated cells on their way to giving rise to a tumor have also to learn how to thrive in a chronically inflamed microenvironment, evade immune recognition, and suppress immune reactivity. Genetic and molecular definition of these three immune hallmarks of cancer offers the opportunity to learn how to deploy specific countermeasures to reverse the situation in favor of the immune system and, eventually, the patient. This new information could be channeled to address what seem to be the three major hallmarks for the immune control of cancer progression: effective procedures to activate immune reactivity; characterization of not-disposable oncoantigens; and counteraction of immune suppression.

引用

页码：319 / 326

页数：8

共 84 条

[1] Vaccine against MUC1 Antigen Expressed in Inflammatory Bowel Disease and Cancer Lessens Colonic Inflammation and Prevents Progression to Colitis-Associated Colon Cancer [J].