Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis

被引：43

作者：

Gavaldà, J ^{[1
]}

Martín, MT ^{[1
]}

López, P ^{[1
]}

Gomis, X ^{[1
]}

Ramírez, JL ^{[1
]}

Rodríguez, D ^{[1
]}

Len, O ^{[1
]}

Puigfel, Y ^{[1
]}

Ruíz, I ^{[1
]}

Pahissa, A ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Hosp Univ Valle Hebron, Div Infect Dis, Infect Dis Res Lab, E-08193 Barcelona, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 07期

关键词：

D O I：

10.1128/AAC.49.7.3028-3030.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels.

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页码：3028 / 3030

页数：3

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