Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

被引：273

作者：

Li, Chen ^{[1
,2
]}

Ni, Yu-Qing ^{[1
,2
]}

Xu, Hui ^{[1
,2
]}

Xiang, Qun-Yan ^{[1
,2
]}

Zhao, Yan ^{[1
,2
]}

Zhan, Jun-Kun ^{[1
,2
]}

He, Jie-Yu ^{[1
,2
]}

Li, Shuang ^{[1
,2
]}

Liu, You-Shuo ^{[1
,2
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Dept Geriatr, Changsha 410011, Hunan, Peoples R China

[2] Cent South Univ, Inst Aging & Age Related Dis Res, Changsha 410011, Hunan, Peoples R China

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2021年 / 6卷 / 01期

基金：

中国国家自然科学基金;

关键词：

MESENCHYMAL STEM-CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACUTE MYOCARDIAL-INFARCTION; GASTRIC-CANCER PROGRESSION; AMYLOID PRECURSOR PROTEIN; TYPE-2; DIABETES-MELLITUS; ISLET BETA-CELL; HEPATOCELLULAR-CARCINOMA; EXTRACELLULAR VESICLES; BREAST-CANCER;

D O I：

10.1038/s41392-021-00779-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are closely related to a variety of biological and functional aspects of human health. When the exosomal ncRNAs undergo tissue-specific changes due to diverse internal or external disorders, they can cause tissue dysfunction, aging, and diseases. In this review, we comprehensively discuss the underlying regulatory mechanisms of exosomes in human diseases. In addition, we explore the current knowledge on the roles of exosomal miRNAs, lncRNAs, and circRNAs in human health and diseases, including cancers, metabolic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and infectious diseases, to determine their potential implication in biomarker identification and therapeutic exploration.

引用

页数：31

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