A Porphyromonas gingivalis genetic locus encoding a heme transport system

被引：51

作者：

Slakeski, N ^{[1
]}

Dashper, SG ^{[1
]}

Cook, P ^{[1
]}

Poon, C ^{[1
]}

Moore, C ^{[1
]}

Reynolds, EC ^{[1
]}

机构：

[1] Univ Melbourne, Sch Dent Sci, Oral Hlth Sci Unit, Melbourne, Vic 3000, Australia

来源：

ORAL MICROBIOLOGY AND IMMUNOLOGY | 2000年 / 15卷 / 06期

关键词：

Porphyromonas gingivalis; TonB-linked receptor; heme transport;

D O I：

10.1034/j.1399-302x.2000.150609.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Porphyromonas gingivalis has been implicated in the onset and progression of periodontitis and the availability of hemin for in vitro growth has been associated with virulence of the bacterium in animal models. We report here the cloning and sequence analysis of a P. gingivalis TonB-linked outer membrane receptor gene tlr. This gene was previously identified as a TonB-linked adhesin gene tla and shown to be essential for growth at low concentrations of hemin. The tlr gene is immediately downstream of four open reading Frames (htrABCD) that encode a putative ATP binding cassette transport system with sequence similarlity to heme transport systems of other bacteria. Analysis of P. gingivalis W50 mRNA revealed that the htrABCD genes are cotranscribed similar to hemin transport genes of other bacteria.

引用

页码：388 / 392

页数：5

共 30 条

[1]

ACTIS LA, 1988, J BIOL CHEM, V263, P2853

[2] The Tla protein of Porphyromonas gingivalis W50: a homolog of the RI protease precursor (PrpRI) is an outer membrane receptor required for growth on low levels of hemin [J].