Templation in the formation of carceplexes

被引：35

作者：

Chapman, RG ^{[1
]}

Sherman, JC ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 12期

关键词：

D O I：

10.1021/jo9803582

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The formation of carceplexes and hemicarceplexes involves an assembly process whereby a molecular template is entrapped between two bowl-shaped molecules. The process can be highly selective such that a million-fold range in template recognition has been realized. The relative template abilities, or template ratios, for 34 molecules in forming carceplex a guest is described. Species with one, two, and three bridges linking the two "bowls" are reported and were used to delineate the guest-determining step of the reaction. The effect of base and solvent on the reaction are also described, and a discussion of the reaction mechanism is presented.

引用

页码：4103 / 4110

页数：8

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