Synthesis of antitumor lycorines by intramolecular Diels-Alder reaction

被引：31

作者：

Perez, D

Bures, G

Guitian, E

Castedo, L

机构：

[1] UNIV SANTIAGO, DEPT QUIM ORGAN, E-15706 SANTIAGO, SPAIN

[2] CSIC, SECC ALCALOIDES, E-15706 SANTIAGO, SPAIN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 05期

关键词：

D O I：

10.1021/jo9518415

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pharmacologically interesting lycorines were obtained by a short, efficient method based on an intramolecular Diels-Alder reaction between an alpha-pyrone and an alkyne, followed by loss of CO2 in a retro Diels-Alder reaction. The cyclization precursors (pyrones 9) were obtained in good yields in two or three steps from the corresponding homophthalic acid or anhydride.

引用

页码：1650 / 1654

页数：5

共 33 条

[1]

[Anonymous], 1968, AMARYLLIDACEAE ALKAL

[2] STUDY OF COPPER-CATALYZED DIRECT ARYLATION OF BETA-DICARBONYL COMPOUNDS WITH 2-BROMOBENZOIC ACIDS [J].