From drug to protein: using yeast genetics for high-throughput target discovery

被引：18

作者：

Armour, CD ^{[1
]}

Lum, PY ^{[1
]}

机构：

[1] Rosetta Inpharmat LLC, Seattle, WA 98109 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2005年 / 9卷 / 01期

关键词：

D O I：

10.1016/j.cbpa.2004.12.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The budding yeast Saccharomyces cerevisiae has long been an effective eukaryotic model system for understanding basic cellular processes. The genetic tractability and ease of manipulation in the laboratory make yeast well suited for large scale chemical and genetic screens. Several recent studies describing the use of yeast genetics for high-throughput drug target identification are discussed in this review.

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收藏

页码：20 / 24

页数：5

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