Matrix metalloproteinases of normal human tissues

被引：38

作者：

Khasigov, PZ

Podobed, OV

Ktzoeva, SA

Gatagonova, TM

Grachev, SV

Shishkin, SS

Berezov, TT

机构：

[1] Sechenov Moscow Med Acad, Moscow 119881, Russia

[2] Russian Acad Med Sci, Med Genet Res Ctr, Moscow 115478, Russia

[3] Patrice Lumumba Peoples Friendship Univ, Moscow 117198, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2001年 / 66卷 / 02期

关键词：

matrix metalloproteinases; tissue inhibitors of matrix metalloproteinases; extracellular matrix;

D O I：

10.1023/A:1002879128392

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review considers biochemical properties of the family of matrix metalloproteinases (MMPs) of normal human tissues and the involvement of these enzymes in morphogenesis. Four main MMP subfamilies are characterized, and a group of other MMPs is described. Data on mechanisms of activation and inhibition of MMPs in certain tissues during various physiological processes (embryogenesis, angiogenesis, tissue growth and involution) are considered. information about tissue inhibitors of MMP is presented, and the ability of these inhibitors to regulate the activity of MMPs is analyzed.

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页码：130 / 140

页数：11

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