Antigen presentation the macrophage way

被引:66
作者
Martinez-Pomares, Luisa
Gordon, Siamon
机构
[1] Univ Nottingham, Queens Med Ctr, Sch Mol Med Sci, Inst Infect Immun & Inflammat, Nottingham NG7 2UH, England
[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
关键词
D O I
10.1016/j.cell.2007.10.046
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Multiphoton intravital microscopy of lymph nodes has revolutionized the study of the early events leading to induction of acquired immunity. Using this technique, Junt et al. (2007) report in a recent issue of Nature that macrophages of the mouse lymph node subcapsular sinus facilitate B cell activation in vivo by collecting and displaying native antigen.
引用
收藏
页码:641 / 643
页数:3
相关论文
共 9 条
[1]   B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node [J].
Carrasco, Yolanda R. ;
Batista, Facundo D. .
IMMUNITY, 2007, 27 (01) :160-171
[2]  
JUNT T, 2007, NATURE 1014
[3]   Identification of sialoadhesin as a dominant lymph node counter-receptor for mouse macrophage galactose-type C-type lectin 1 [J].
Kumamoto, Y ;
Higashi, N ;
Denda-Nagai, K ;
Tsuiji, M ;
Sato, K ;
Crocker, PR ;
Irimura, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (47) :49274-49280
[4]   The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles [J].
Pape, Kathryn A. ;
Catron, Drew M. ;
Itano, Andrea A. ;
Jenkins, Marc K. .
IMMUNITY, 2007, 26 (04) :491-502
[5]   Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells [J].
Phan, Tri Giang ;
Grigorova, Irina ;
Okada, Takaharu ;
Cyster, Jason G. .
NATURE IMMUNOLOGY, 2007, 8 (09) :992-1000
[6]   Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells [J].
Qi, Hai ;
Egen, Jackson G. ;
Huang, Alex Y. C. ;
Germain, Ronald N. .
SCIENCE, 2006, 312 (5780) :1672-1676
[7]   The mannose receptor: linking homeostasis and immunity through sugar recognition [J].
Taylor, PR ;
Gordon, S ;
Martinez-Pomares, L .
TRENDS IN IMMUNOLOGY, 2005, 26 (02) :104-110
[8]   Macrophage receptors and immune recognition [J].
Taylor, PR ;
Martinez-Pomares, L ;
Stacey, M ;
Lin, HH ;
Brown, GD ;
Gordon, S .
ANNUAL REVIEW OF IMMUNOLOGY, 2005, 23 :901-944
[9]   B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion [J].
Yu, P ;
Wang, Y ;
Chin, RK ;
Martinez-Pomares, L ;
Gordon, S ;
Kosco-Vibois, MH ;
Cyster, J ;
Fu, YX .
JOURNAL OF IMMUNOLOGY, 2002, 168 (10) :5117-5123