Noncovalent linking of a chiral selector to unmodified silica gel through amine functional groups

被引：3

作者：

Wu, YQ ^{[1
]}

Krocka, M ^{[1
]}

Li, TY ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 1998年 / 822卷 / 01期

关键词：

noncovalent linking; kinetic coating; chiral selectors; chiral stationary phases; LC; amines; quaternary ammonium;

D O I：

10.1016/S0021-9673(98)00491-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The noncovalent linking of Pirkle's dinitrobenzoyl-L-leucine chiral selector to unmodified silica gel by means of polar moieties such as amines and quaternary ammonium ions was studied. Selectors linked with amine groups provided resolution of racemic 2,2,2-trifluoro-1-(9-anthryl)ethanol comparable to that of Pirkle's column having a covalently bonded selector. Non-covalent linking by means of the quaternary ammonium ion group was much less efficient in resolving optical isomers. (C) 1998 Elsevier Science B.V. All rights reserved.

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收藏

页码：11 / 18

页数：8

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