Histone deacetylase inhibitors in programmed cell death and cancer therapy

被引:143
作者
Marks, PA [1 ]
Jiang, XJ [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA
关键词
HDAC inhibitors; cancer therapy; apoptosis; autophagic cell death; thioredoxin;
D O I
10.4161/cc.4.4.1564
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Histone deacetylase ( HDAC) inhibitors, such as suberoylanilide hydroxamic acid ( SAHA), are targeted anticancer agents that have significant anticancer activity at doses well tolerated by patients. 1 Recently, we found that HDAC inhibitors can trigger both mitochondria-mediated apoptosis and caspase-independent autophagic cell death, indicating potential benefit of HDAC inhibitors in treating cancers with apoptotic defects. 2 We also found that thioredoxin (TRX) might play a significant role in HDAC inhibitor-induced cell death, and HDAC inhibitors increase TRX levels in normal cells but not transformed cells, which is likely to be one of the reasons why HDAC inhibitors preferentially kill cancer cells. 3 In this review, we discuss the study of HDAC inhibitors in cell death and cancer research, the implications of our recent findings, and some outstanding questions that need to be addressed.
引用
收藏
页码:549 / 551
页数:3
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