Highly diastereoselective synthesis of 1,3-oxazolidines under thermodynamic control using focused microwave irradiation under solvent-free conditions

被引：48

作者：

Kuhnert, N ^{[1
]}

Danks, TN ^{[1
]}

机构：

[1] Univ Surrey, Dept Chem, Synthet & Biol Organ Chem Lab, Guildford GU2 7XH, Surrey, England

来源：

GREEN CHEMISTRY | 2001年 / 3卷 / 02期

关键词：

D O I：

10.1039/b008866h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A number of 1,3-oxazolidines, derived from enantiomerically pure amino alcohols such as (-)-ephedrine and (+)-pseudoephedrine, have been synthesised under solvent-free conditions using a focused microwave reactor. The condensation reaction between the amino alcohol and an aldehyde yields 1,3-oxazolidines in excellent yields and diastereoselectivities. Prolonged microwave irradiation increases the diastereoselectivity of the reaction and produces the thermodynamically more stable diastereomer.

引用

页码：68 / 70

页数：3

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