Immune-deficient mouse models for analysis of human stem cells

被引：43

作者：

Meyerrose, TE ^{[1
]}

Herrbrich, P ^{[1
]}

Hess, DA ^{[1
]}

Nolta, JA ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Internal Med, Div Oncol,Sect Hematopoiet Dev & Malignancy, St Louis, MO 63110 USA

来源：

BIOTECHNIQUES | 2003年 / 35卷 / 06期

关键词：

D O I：

10.2144/03356ss06

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The field of murine models of xenotransplantation has grown immensely over the past two decades. The explosive growth in this field is in part due to the fact that good in vitro methods do not exist yet to allow examination of human stem cell homing into the bone marrow compartment versus other tissues, long-term survival of human stem cells, or differentiation into tissues outside of the hematopoietic system. Since these important aspects of human stem cell biology can be examined in vivo using immune-deficient mice, the number of different strains and models is constantly increasing. The current review discusses the merits and drawbacks of each immune-deficient mouse xenograft system as it stands to date and reviews how each immune-deficient mouse model has been used to further our knowledge of human hematopoietic stem cell biology.

引用

页码：1262 / +

页数：12

共 106 条

[1] Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero [J].