A topological view of the replicon

被引：100

作者：

Schvartzman, JB

Stasiak, A

机构：

[1] CSIC, Ctr Invest Biol, Dept Biol Celular & Desarrollo, Madrid 28040, Spain

[2] Univ Lausanne, Lab Anal Ultrastruct, CH-1015 Lausanne, Switzerland

来源：

EMBO REPORTS | 2004年 / 5卷 / 03期

关键词：

replication; plasmid; supercoiling; catenane; knot;

D O I：

10.1038/sj.embor.7400101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The replication of circular DNA faces topological obstacles that need to be overcome to allow the complete duplication and separation of newly replicated molecules. Small bacterial plasmids provide a perfect model system to study the interplay between DNA helicases, polymerases, topoisomerases and the overall architecture of partially replicated molecules. Recent studies have shown that partially replicated circular molecules have an amazing ability to form various types of structures (supercoils, precatenanes, knots and catenanes) that help to accommodate the dynamic interplay between duplex unwinding at the replication fork and DNA unlinking by topoisomerases.

引用

页码：256 / 261

页数：6

共 56 条

[1] Mechanisms of separation of the complementary strands of DNA during replication [J].