Magnetic driven alginate nanoparticles for targeted drug delivery

被引：22

作者：

Ciofani, Gianni ^{[1
,2
]}

Raffa, Vittoria ^{[1
]}

Obata, Yosuke ^{[3
]}

Menciassi, Arianna ^{[1
,4
]}

Dario, Paolo ^{[1
,4
]}

Takeoka, Shinji ^{[2
,3
]}

机构：

[1] Scuola Super Sant Anna, Ctr Res Microengn, CRIM Lab, I-56025 Pontedera, PI, Italy

[2] Waseda Univ, Japan Joint Lab RoboCasa, Shinjuku Ku, Tokyo 1698555, Japan

[3] Waseda Univ, Sch Adv Sci & Engn, Dept Life Sci & Med Biosci, Shinjuku Ku, Tokyo 1698555, Japan

[4] Italian Inst Technol, Genoa, Italy

来源：

CURRENT NANOSCIENCE | 2008年 / 4卷 / 02期

关键词：

drug delivery system; alginate nanoparticles; magnetic nanoparticles; magnetic driven drug delivery;

D O I：

10.2174/157341308784340886

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The aim of this paper is to develop highly magnetized, biodegradable and biocompatible, polymeric nanoparticles for drug delivery in cell therapy. Alginate magnetic nanoparticles are realized by an emulsion/reticulation technique, after the dispersion of magnetite in an alginate solution. Such nanoparticles are characterized in terms of external morphology (FIB imaging), microstructure (TEM imaging), size distribution, zeta potential, magnetic properties (SQUID analysis) and drug release behaviour. Magnetization curves show the typical trend of superparamagnetic materials. Important parameters, such as magnetic permeability and magnetic momentum, are derived by employing Langevin theory. Experimental results reveal that a bi-exponential model fully describes the drug release. Finally, in vitro experiments on NIH/3T3 cells are carried out and demonstrate that our magnetic alginate nanoparticles can effectively drive the drug delivery towards an external magnetic field source.

引用

页码：212 / 218

页数：7

共 31 条

[1] Magnetic nanoparticles for drug delivery [J].