Dermatofibrosarcoma protuberans harboring t(9;22)(q32;q12.2)

被引：34

作者：

Sonobe, H ^{[1
]}

Furihata, M

Iwata, J

Ohtsuki, Y

Chikazawa, M

Taguchi, T

Shimizu, K

机构：

[1] Kochi Med Sch, Dept Pathol, Nanko Ku, Kochi 7838505, Japan

[2] Kochi Med Sch, Dept Dermatol, Nanko Ku, Kochi 7838505, Japan

[3] Kochi Med Sch, Dept Anat, Nanko Ku, Kochi 7838505, Japan

[4] Shionogi Biomed Labs, Settsu, Osaka, Japan

来源：

CANCER GENETICS AND CYTOGENETICS | 1999年 / 110卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(98)00183-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

More than 20 cases of dermatofibrosarcoma protuberans (DFSP) exhibiting chromosomal abnormalities have been reported. Approximately three fourths of these tumors have harbored supernumerary ring chromosomes, which have been suggested to be specific for this tumor. However, a small number of DFSPs with translocations such as t(2;17), t(X;7), and t(17;22) have recently been reported. We report a DFSP arising in a 23-year-old woman which unexpectedly exhibited the balanced translocation, t(9;22)(q32;q12.2) as the only anomaly with G-band technique. Dual-color fluorescence in situ hybridization: (FISH) confirmed these cytogenetic findings. Similar to that previously reported for DFSPs with translocations, the present tumor also lacked ring chromosomes. (C) Elsevier Science Inc., 1999. All rights reserved.

引用

页码：14 / 18

页数：5

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