NPHS2 mutations

被引：7

作者：

Bakr, Ashraf ^{[1
]}

Yehia, Soheir ^{[2
]}

El-Ghannam, Doaa ^{[3
]}

Hammad, Ayman

Ragab, Mohamed

Sarhan, Amr

Al-Husseni, Fatma ^{[4
]}

Al-Morsy, Zakaria ^{[2
]}

机构：

[1] Mansoura Univ, Childrens Hosp, Mansoura Fac Med, Dept Pediat Nephrol, Mansoura, Egypt

[2] Mansoura Univ, Childrens Hosp, Dept Genet, Mansoura, Egypt

[3] Mansoura Univ, Childrens Hosp, Dept Clin Pathol, Mansoura, Egypt

[4] Mansoura Univ, Childrens Hosp, Dept Pathol, Mansoura, Egypt

来源：

INDIAN JOURNAL OF PEDIATRICS | 2008年 / 75卷 / 02期

关键词：

Egyptian children; nephrotic syndrome; non familial; NPHS2; mutations; steroid resistant;

D O I：

10.1007/s12098-008-0020-y

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Objective. To uncover the frequency and the spectrum of NPHS2 mutations in Egyptian children with non familial steroid-resistant nephrotic syndrome (SRNS). Methods. Sixteen patients were screened by PCR-single-strand conformation polymorphism analysis of NPHS2 gene followed by direct sequencing. Results. NPHS2 mutations were evident in four patients (25%) who were bearing four novel mutations including two frame shift mutations (R238fs and P45fs) and two missense mutations (I136L and F216Y). There were no phenotypic or histological characteristics of patients bearing NPHS2 mutations, apart from the earlier onset of the disease, compared to those who were not bearing mutations. Conclusion. NPHS2 mutations are prevalent in Egyptian children with non-familial SRNS and this may in part explain the less favorable prognosis reported in these patients.

引用

页码：135 / 138

页数：4

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