Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3:: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

被引：17

作者：

Fujishima, T

Kittaka, A

Yamaoka, K

Takeyama, K

Kato, S

Takayama, H ^{[1
]}

机构：

[1] Teikyo Univ, Fac Pharmaceut Sci, Kanagawa 1990195, Japan

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 11期

关键词：

D O I：

10.1039/b302017g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise synthesis of all four possible A-ring stereoisomers of 2,2-dimethyl-1,25-dihydroxyvitamin D-3 and characterization of their distinct transcriptional features, which appear to have been inherited from the corresponding 2alpha-methyl derivatives, is reported.

引用

收藏

页码：1863 / 1869

页数：7

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