Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT1A Receptor

被引：41

作者：

Shin, Eun-Joo ^{[1
]}

Whang, Wan Kyunn ^{[3
]}

Kim, Sungun ^{[3
]}

Bach, Jae-Hyung ^{[1
]}

Kim, Jin-Man ^{[1
]}

Nguyen, Xuan-Khanh Thi ^{[1
]}

Nguyen, Thuy-Ty Lan ^{[1
]}

Jung, Bae Dong ^{[2
]}

Yamada, Kiyofumi ^{[4
,5
]}

Nabeshima, Toshitaka ^{[6
]}

Kim, Hyoung-Chun ^{[1
]}

机构：

[1] Kangwon Natl Univ, Neuropsychopharmacol & Toxicol Program, Coll Pharm, Chunchon 200701, South Korea

[2] Kangwon Natl Univ, Sch Vet Med, Chunchon 200701, South Korea

[3] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea

[4] Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol, Nagoya, Aichi 4668560, Japan

[5] Nagoya Univ, Grad Sch Med, Hosp Pharm, Nagoya, Aichi 4668560, Japan

[6] Meijo Univ, Grad Sch Pharmaceut Sci, Dept Chem Pharmacol, Nagoya, Aichi 4688503, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2010年 / 113卷 / 04期

关键词：

parishin C; phencyclidine; 5-HT1A receptor; GASTRODIA ELATA; SEROTONIN; RAT; MEMBRANES; DEFICITS; RHIZOMES; BINDING; CORTEX;

D O I：

10.1254/jphs.10040SC

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviours in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C These effects were reversed by WAY 100635, a 5-HT1A-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A-agonist activity in a 8-OH-DPAT-stimulated [35S]GTP-gamma S binding assay Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors.

引用

页码：404 / 408

页数：5

共 15 条

[1]

Characterization of 5-HT1A receptor-mediated [35S]GTPγS binding in rat hippocampal membranes [J].