Plasma 25-Hydroxyvitamin D Concentration and Risk of Incident Type 2 Diabetes in Women

被引：169

作者：

Pittas, Anastassios G. ^{[1
,2
]}

Sun, Qi ^{[3
,4
,5
]}

Manson, Joann E. ^{[3
,4
,5
,6
]}

Dawson-Hughes, Bess ^{[1
,7
]}

Hu, Frank B. ^{[3
,4
,5
]}

机构：

[1] Tufts Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA USA

[2] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA

[3] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[5] Harvard Univ, Sch Med, Boston, MA USA

[6] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA

[7] Tufts Univ, Bone Metab Lab, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Boston, MA 02111 USA

来源：

DIABETES CARE | 2010年 / 33卷 / 09期

基金：

美国国家卫生研究院;

关键词：

VITAMIN-D; CALCIUM; HEALTH;

D O I：

10.2337/dc10-0790

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - To determine the association between 25-hydroxyvitamin D (25-OHD) concentration and risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS - In a nested case-control study conducted among 608 women with newly diagnosed type 2 diabetes and 559 control subjects in the Nurses' Health Study, we measured the association between baseline plasma 25-OHD concentration and risk of incident diabetes. RESULTS - After adjusting for matching factors and diabetes risk factors, including BMI, higher levels of plasma 25-OHD were associated with a lower risk for type 2 diabetes. The odds ratio for incident type 2 diabetes in the top (median 25-OHD, 33.4 ng/ml) versus the bottom (median 25-OHD, 14.4 ng/ml) quartile was 0.52 (95% Cl 0.33-0.83). The associations were consistent across subgroups of baseline BMI, age, and calcium intake. CONCLUSIONS - Plasma 25-OHD concentration was associated with lower risk of incident type 2 diabetes in women.

引用

页码：2021 / 2023

页数：3

共 10 条

[1] The Nurses' Health Study: Lifestyle and health among women [J].