In vivo chromatin remodeling by yeast ISWI homologs Isw1p and Isw2p

被引：97

作者：

Kent, NA ^{[1
]}

Karabetsou, N ^{[1
]}

Politis, PK ^{[1
]}

Mellor, J ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, Div Mol Genet, Oxford OX1 3QU, England

来源：

GENES & DEVELOPMENT | 2001年 / 15卷 / 05期

关键词：

yeast; chromatin; transcription; Isw1p; Isw2p; chromatin-remodeling ATPase;

D O I：

10.1101/gad.190301

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Isw1p and Isw2p are budding yeast homologs of the Drosophila ISWI chromatin-remodeling ATPase. Using indirect-end-label and chromatin immunoprecipitation analysis, we show both independent and cooperative Isw1p- and Isw2p-mediated positioning of short nucleosome arrays in gene-regulatory elements at a variety of transcription units in vivo. We present evidence that both yeast ISWI complexes regulate developmental responses to starvation and that for Isw2p, recruitment by different DNA-binding proteins controls meiosis and haploid invasive growth.

引用

页码：619 / 626

页数：8

共 35 条

[1] REMOVAL OF POSITIONED NUCLEOSOMES FROM THE YEAST PHO5 PROMOTER UPON PHO5 INDUCTION RELEASES ADDITIONAL UPSTREAM ACTIVATING DNA ELEMENTS [J].

ALMER, A ;

RUDOLPH, H ;

HINNEN, A ;

HORZ, W .

EMBO JOURNAL, 1986, 5 (10) :2689-2696

[2]

AVEDANO A, 1997, J BACTERIOL, V179, P5594

[3] dMi-2 and ISWI chromatin remodelling factors have distinct nucleosome binding and mobilization properties [J].

Brehm, A ;

Längst, G ;

Kehle, J ;

Clapier, CR ;

Imhof, A ;

Eberharter, A ;

Müller, J ;

Becker, PB .

EMBO JOURNAL, 2000, 19 (16) :4332-4341

[4] Chromatin remodeling machines: similar motors, ulterior motives [J].

Cairns, BR .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (01) :20-25

[5] Role for Drs2p, a P-type ATPase and potential aminophospholipid translocase, in yeast late Golgi function [J].

Chen, CY ;

Ingram, MF ;

Rosal, PH ;

Graham, TR .

JOURNAL OF CELL BIOLOGY, 1999, 147 (06) :1223-1236

[6] The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo [J].

Deuring, R ;

Fanti, L ;

Armstrong, JA ;

Sarte, M ;

Papoulas, O ;

Prestel, M ;

Daubresse, G ;

Verardo, M ;

Moseley, SL ;

Berloco, M ;

Tsukiyama, T ;

Wu, C ;

Pimpinelli, S ;

Tamkun, JW .

MOLECULAR CELL, 2000, 5 (02) :355-365

[7] Pheromone-regulated genes required for yeast mating differentiation [J].

Erdman, S ;

Lin, L ;

Malczynski, M ;

Snyder, M .

JOURNAL OF CELL BIOLOGY, 1998, 140 (03) :461-483

[8] The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p [J].

Goldmark, JP ;

Fazzio, TG ;

Estep, PW ;

Church, GM ;

Tsukiyama, T .

CELL, 2000, 103 (03) :423-433

[9] ATP-dependent histone octamer sliding mediated by the chromatin remodeling complex NURF [J].

Hamiche, A ;

Sandaltzopoulos, R ;

Gdula, DA ;

Wu, C .

CELL, 1999, 97 (07) :833-842

[10] THE TRANSCRIPTION FACTOR, THE CDK, ITS CYCLIN AND THEIR REGULATOR - DIRECTING THE TRANSCRIPTIONAL RESPONSE TO A NUTRITIONAL SIGNAL [J].

HIRST, K ;

FISHER, F ;

MCANDREW, PC ;

GODING, CR .

EMBO JOURNAL, 1994, 13 (22) :5410-5420

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