Synthesis of analogues of the O-β-D-ribofuranosyl nucleoside moiety of liposidomycins.: part 1:: Contribution of the amino group and the uracil moiety upon the inhibition of MraY

被引：56

作者：

Dini, C

Drochon, N

Feteanu, S

Guillot, JC

Peixoto, C

Aszodi, J

机构：

[1] Aventis Pharma, Dept Med Chem, F-93235 Romainville, France

[2] Aventis Pharma, Infect Dis Grp, F-93235 Romainville, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)00715-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The O-beta -D-ribofuranosyl nucleoside I is the minimal structural entity of liposidomycins maintaining enzyme inhibitory activity. Modifications performed on both the primary amine and the uracil moieties clearly demonstrate their major contribution to the inhibition of the bacterial translocase (MraY). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：529 / 531

页数：3

共 7 条

[1]

Boyle DS, 1998, J BACTERIOL, V180, P6429

[2] Synthesis of the nucleoside moiety of liposidomycins: Elucidation of the pharmacophore of this family of MraY inhibitors [J].