SIR1, an upstream component in auxin signaling identified by chemical genetics

被引：130

作者：

Zhao, YD

Dai, XH

Blackwell, HE

Schreiber, SL

Chory, J

机构：

[1] Univ Calif San Diego, Div Biol Sci, Sect Cell & Dev Biol, La Jolla, CA 92093 USA

[2] Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

[3] Salk Inst Biol Studies, La Jolla, CA 92037 USA

[4] HHMI, Plant Biol Lab, La Jolla, CA 92037 USA

来源：

SCIENCE | 2003年 / 301卷 / 5636期

关键词：

D O I：

10.1126/science.1084161

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Auxin is a plant hormone that regulates many aspects of plant growth and development. We used a chemical genetics approach to identify SIR1, a regulator of many auxin-inducible genes. The sir1 mutant was resistant to sirtinol, a small molecule that activates many auxin-inducible genes and promotes auxin-related developmental phenotypes. SIR1 is predicted to encode a protein composed of a ubiquitin-activating enzyme E1-like domain and a Rhodanese-like domain homologous to that of prolyl isomerase. We suggest a molecular context for how the auxin signal is propagated to exert its biological effects.

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页码：1107 / 1110

页数：4

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