Therapeutic potential of selective modulators of nuclear receptor action

被引：64

作者：

Resche-Rigon, M

Gronemeyer, H

机构：

[1] Hoechst Marion Roussel, F-93235 Romainville, France

[2] ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

[3] Ctr Univ Strasbourg, Strasbourg, France

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(98)80126-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear receptors belong to a superfamily of ligand-inducible transcription factors that, in addition to directly regulating their cognate gene programs, can also mutually interfere with other signaling pathways, The recent identification of selective agonists/antagonists of the glucocorticoid, retinoid and estrogen receptors suggests that it might be possible to selectively elicit only a subset of the nuclear receptor functions that are induced by the natural ligand, with the aim of increasing the functional and, perhaps, tissue selectivity of nuclear receptor ligands and reducing unwanted side effects.

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页码：501 / 507

页数：7

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