High-performance liquid chromatographic determination of meropenem in rat plasma using column-switching

被引：10

作者：

Lee, HS ^{[1
]}

Shim, HO ^{[1
]}

Yu, SR ^{[1
]}

机构：

[1] KOREA RES INST CHEM TECHNOL,TOXICOL RES CTR,TAEJON 305606,SOUTH KOREA

来源：

CHROMATOGRAPHIA | 1996年 / 42卷 / 7-8期

关键词：

column liquid chromatography; meropenem in rat plasma; column-switching;

D O I：

10.1007/BF02272131

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of this study was to develop a column-switching HPLC method for the determination of meropenem in plasma. This method showed excellent precision and accuracy with good sensitivity and speed. The total analysis time per sample was less than 20 min and the mean coefficients of variation for intra- and inter-assay were less than 4.0 %. The method has been successfully applied to plasma samples from rats receiving an intraperitoneal injection of meropenem.

引用

页码：405 / 408

页数：4

共 18 条

[1] THE PHARMACOKINETICS OF MEROPENEM IN VOLUNTEERS [J].

BAX, RP ;

BASTAIN, W ;

FEATHERSTONE, A ;

WILKINSON, DM ;

HUTCHISON, M ;

HAWORTH, SJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1989, 24 :311-320

[2]

BURMAN LA, 1991, J ANTIMICROB CHEMOTH, V27, P219

[3] PHARMACOKINETICS OF MEROPENEM IN PATIENTS WITH VARIOUS DEGREES OF RENAL-FUNCTION, INCLUDING PATIENTS WITH END-STAGE RENAL-DISEASE [J].

CHIMATA, M ;

NAGASE, M ;

SUZUKI, Y ;

SHIMOMURA, M ;

KAKUTA, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (02) :229-233

[4] INVITRO ANTIBACTERIAL ACTIVITY OF SM-7338, A CARBAPENEM ANTIBIOTIC WITH STABILITY TO DEHYDROPEPTIDASE-I [J].

EDWARDS, JR ;

TURNER, PJ ;

WANNOP, C ;

WITHNELL, ES ;

GRINDEY, AJ ;

NAIRN, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (02) :215-222

[5]

FUGASAWA M, 1992, ANTIMICROB AGENTS CH, V36, P1577

[6] THE DISPOSITION AND METABOLISM OF MEROPENEM IN LABORATORY-ANIMALS AND MAN [J].

HARRISON, MP ;

MOSS, SR ;

FEATHERSTONE, A ;

FOWKES, AG ;

SANDERS, AM ;

CASE, DE .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1989, 24 :265-277

[7] SIMULTANEOUS DETERMINATION OF IBUPROXAM AND IBUPROFEN IN HUMAN PLASMA BY HPLC WITH COLUMN-SWITCHING [J].

JUNG, ES ;

LEE, HS ;

RHO, JK ;

KWON, KI .

CHROMATOGRAPHIA, 1993, 37 (11-12) :618-622

[8] SIMULTANEOUS DETERMINATION OF CEFAMANDOLE AND CEFAMANDOLE NAFATE IN HUMAN PLASMA AND URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH COLUMN SWITCHING [J].

LEE, HS ;

ZEE, OP ;

KWON, KI .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 528 (02) :425-433

[9] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF RIFAPENTINE IN SERUM USING COLUMN SWITCHING [J].

LEE, HS ;

SHIN, HC ;

HAN, SS ;

ROH, JK .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1992, 574 (01) :175-178

[10] SIMULTANEOUS DETERMINATION OF AMPICILLIN AND METAMPICILLIN IN BIOLOGICAL-FLUIDS USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH COLUMN-SWITCHING [J].

LEE, HY ;

LEE, JS ;

LEE, HS .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 664 (02) :335-340

← 1 2 →