Biological monitoring of a xenomaterial for grafting: an evaluation in critical-size calvarial defects

被引：9

作者：

Accorsi-Mendonca, Thais ^{[2
]}

Zambuzzi, Willian Fernando ^{[4
,7
]}

Bramante, Clovis Monteiro ^{[3
]}

Cestari, Tania Mari ^{[5
]}

Taga, Rumio ^{[5
]}

Sader, Marcia ^{[6
]}

de Almeida Soares, Gloria Dulce ^{[6
]}

Granjeiro, Jose Mauro ^{[1
,4
,7
]}

机构：

[1] Univ Fed Fluminense, Dept Cell & Mol Biol, Inst Biol, UFF, BR-24020150 Centro Niteroi, RJ, Brazil

[2] Univ Grande Rio, Dept Endodont, BR-25071202 Duque De Caxias, RJ, Brazil

[3] Univ Sao Paulo, Dept Endodont, Bauru Dent Sch, Sao Paulo, Brazil

[4] Standardizat & Ind Qual INMETRO, Projects Div, Natl Inst Metrol, Rio De Janeiro, Brazil

[5] Univ Sao Paulo, Dept Biol Sci, Bauru Dent Sch, Sao Paulo, Brazil

[6] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil

[7] Univ Hosp Antonio Pedro, Cell therapy Ctr, Niteroi, RJ, Brazil

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2011年 / 22卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

BOVINE BONE; IMPLANTATION; SUBSTITUTE; ADHESION; PROTEIN;

D O I：

10.1007/s10856-011-4278-7

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Our purpose was to evaluate the osteoconduction potential of mixed bovine bone (MBB) xenografts as an alternative for bone grafting of critical-size defects in the calvaria of rats. After surgery, in the time intervals of 1, 3, 6, and 9 months, rats were killed and their skulls collected, radiographed and histologically prepared for analysis. The data obtained from histological analysis reported that the particles of MBB did not promote an intense immunological response, evidencing its biocompatibility in rats. Our results clearly showed the interesting evidence that MBB was not completely reabsorbed at 9 months while a small amount of newly formed bone was deposited by osteoprogenitor cells bordering the defect. However, this discrete bone-forming stimulation was unable to regenerate the bone defect. Overall, our results suggest that the properties of MBB are not suitable for stimulating intense bone regeneration in critical bone defects in rats.

引用

页码：997 / 1004

页数：8

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