Anti-inflammatory agents and cognitive decline in a bi-racial population

被引：19

作者：

Grodstein, Francine ^{[1
,2
,4
]}

Skarupski, Kimberly A. ^{[2
,4
]}

Bienias, Julia L. ^{[2
,4
]}

Wilson, Robert S. ^{[3
,5
,6
]}

Bennett, David A. ^{[3
,5
]}

Evans, Denis A. ^{[2
,4
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Channing Lab, Boston, MA 02115 USA

[2] Rush Univ, Med Ctr, Rush Inst Healthy Aging, Chicago, IL 60612 USA

[3] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

[4] Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA

[5] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[6] Rush Univ, Med Ctr, Dept Psychol, Chicago, IL 60612 USA

来源：

NEUROEPIDEMIOLOGY | 2008年 / 30卷 / 01期

关键词：

Chicago health and aging project; nonsteroidal anti-inflammatory drugs; cognitive function;

D O I：

10.1159/000115749

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 [公共卫生与预防医学]; 120402 [社会医学与卫生事业管理];

摘要：

In a prospective study among 4,409 subjects aged 65+ years, we assessed the relation of nonsteroidal anti-inflammatory agents (NSAIDs) to cognition. The main outcome was decline in global cognitive function, determined by average performance across four cognitive tests, over up to four interviews. We found similar rates of cognitive decline among recent users of aspirin and of other NSAIDs (largely ibuprofen) compared to those who did not use these NSAIDs. For lifetime duration of aspirin use, we failed to find an association with cognitive decline. However, for other NSAIDs, increasing duration of lifetime use was related to slower rates of cognitive decline, relative to no use of other NSAIDs (5+ years vs. no use: mean difference = 0.12; p trend = 0.03). Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons. Copyright (c) 2008 S. Karger AG, Basel.

引用

页码：45 / 50

页数：6

共 18 条

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