Chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chernobyl NPP accident - With focus on immunoglobulin heavy chain gene analysis

被引：20

作者：

Abramenko, Iryna ^{[1
]}

Bilous, Nadia ^{[1
]}

Chumak, Anatoliy ^{[1
]}

Davidova, Ekaterina ^{[2
]}

Kryachok, Iryna ^{[1
]}

Martina, Zoya ^{[1
]}

Nechaev, Stanislav ^{[1
]}

Dyagil, Lryna ^{[1
]}

Bazyka, Dmytriy ^{[1
]}

Bebeshko, Vladimir ^{[1
]}

机构：

[1] Ukraine Acad Med Sci, RCRM, UA-04053 Kiev, Ukraine

[2] All Russian Ctr Qual & Standardizat Vet Medicat F, Moscow, Russia

来源：

LEUKEMIA RESEARCH | 2008年 / 32卷 / 04期

关键词：

chronic lymphocytic leukemia; ionizing radiation; immunoglobulin variable heavy chain (IgVH) gene usage;

D O I：

10.1016/j.leukres.2007.08.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clinical data and immunoglobulin variable heavy chain (IgVH) gene configuration were analyzed in 47 CLL patients, exposed to ionizing radiation (IR) due to Chernobyl NPP accident, and 141 non-exposed patients. Clean-up workers of the second quarter of 1986 (n = 19) were picked Out as separate group with the highest number of unmutated cases (94.4%), increased usage of IgVH1-69 (33.3%) and IgVH3-21 (16.7%) genes, high frequency of secondary solid tumors (6 cases) and Richter transformation (4 cases). These preliminary data suggest that CLL in the most Suffered contingent due to Chernobyl NPP accident might have some specific features. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：535 / 545

页数：11

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