ε-secretase:: Reduction of amyloid precursor protein ε-site cleavage in Alzheimer's disease

被引：15

作者：

Kametani, Fuyuki ^{[1
]}

机构：

[1] Tokyo Metropolitan Org Med Res, Tokyo Inst Psychiat, Setagaya Ku, Tokyo 1568585, Japan

来源：

CURRENT ALZHEIMER RESEARCH | 2008年 / 5卷 / 02期

关键词：

Alzheimer's disease; APP; presenilin; gamma-secretase; A beta AICD; epsilon-secretase;

D O I：

10.2174/156720508783954776

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The accumulation and deposition of fibrillar A beta is thought the primary cause of Alzheimer's disease (AD). A beta is generated by sequential proteolytic processing involving beta- and gamma-secretase on Amyloid beta protein precursor (APP). Recently, gamma-secretase was shown to cleave near the cytoplasmic membrane boundary of APP, called gamma-site cleavage, as well as in the middle of the membrane domain, called site cleavage. Recent findings indicate that gamma- and epsilon-site cleavage are regulated independently. In this review, the reduction of epsilon-site cleavage in AD and the importance of epsilon-site cleavage are discussed.

引用

页码：165 / 171

页数：7

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