Periocular mucosa-associated lymphoid/low grade lymphomas: Treatment with antibiotics

PURPOSE: To report on the treatment of primary mucosa-\associated lymphoid tumors (MALT)Aow grade lympho mas of the conjunctiva/orbit treated solely with systemic antibiotics. DESIGN: Retrospective interventional case series. METHODS: Three adult patients with biopsy/marker proven MALT lymphomas of the conjunctiva/orbit were treated with systemic antibiotics and followed for signs of local or systemic relapse. RESULTS: All three patients showed a response to antibiotics based on clinical, ultrasonographic, and MRI/CT imaging studies. Two patients have had complete remissions (42 months follow,up) and one a partial remission (18 months). No systemic relapses have occurred. CONCLUSION: MALT/Iow grade lymphomas of the con, junctiva/orbit respond to systemic antibiotic therapy and may have complete remissions.