[Gallium(III) protoporphyrin IX]2: A Soluble Diamagnetic Model for Malaria Pigment

被引：15

作者：

Bohle, D. Scott ^{[1
]}

Dodd, Erin L. ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

INORGANIC CHEMISTRY | 2012年 / 51卷 / 08期

基金：

加拿大自然科学与工程研究理事会;

关键词：

BETA-HEMATIN; ANTIMALARIAL; HEMOZOIN;

D O I：

10.1021/ic2027303

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学];

摘要：

Gallium(III) protoporphyrin IX forms a dimeric propionate-bridged dimer, 2, that is a soluble diamagnetic analogue of hematin anhydride. The single-crystal structure of 2 corresponds to a nondisordered inversion-symmetric dimer similar to malaria pigment but, unlike it, has a six-coordinate metal and an intraporphyrin rather than an interporphyrin hydrogen bond. NMR NOE correlations demonstrate the presence of the propionate linkage in solutions with pyridine. Taken together, this is the first single-crystal X-ray diffraction study of a propionate-linked dimer as found in malaria pigment and the first evidence for its presence in solution.

引用

页码：4411 / 4413

页数：3

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