RETRACTED: Differential impact of diabetes and hypertension in the brain: Adverse effects in grey matter (Retracted article. See vol. 68, pg. 229, 2014)

被引：25

作者：

DeVisser, Adriena ^{[1
,2
]}

Yang, Christina ^{[1
,2
]}

Herring, Amanda ^{[1
,2
]}

Martinez, Jose A. ^{[1
,2
]}

Rosales-Hernandez, Alma ^{[1
,2
]}

Poliakov, Ilia ^{[1
,2
]}

Ayer, Amit ^{[1
,2
]}

Garven, Alexandra ^{[1
,2
]}

Zaver, Shaila ^{[1
,2
]}

Rincon, Natalia ^{[1
,2
]}

Xu, Kevin ^{[1
,2
]}

Tuor, Ursula I. ^{[1
,2
,3
,4
]}

Schmidt, Ann Marie ^{[5
]}

Toth, Cory ^{[1
,2
]}

机构：

[1] Univ Calgary, Dept Clin Neurosci, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB T2N 4N1, Canada

[3] Univ Calgary, Natl Res Council, Inst Biodiagnost W, Calgary, AB T2N 4N1, Canada

[4] Univ Calgary, Expt Imaging Ctr, Calgary, AB T2N 4N1, Canada

[5] Columbia Univ, Dept Surg, New York, NY USA

来源：

NEUROBIOLOGY OF DISEASE | 2011年 / 44卷 / 02期

关键词：

Diabetes; Hypertension; Cerebral atrophy; White matter abnormalities; Vascular disease; Insulin receptor; PROGENITOR PROLIFERATION; COGNITIVE DYSFUNCTION; SYNAPTIC PLASTICITY; INSULIN; MELLITUS; RECEPTOR; HYPERINTENSITIES; POPULATION; HIPPOCAMPUS; ASSOCIATION;

D O I：

10.1016/j.nbd.2011.06.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Diabetes mellitus types 1 and 2 (DM1 and DM2) and/or hypertension (HTN) can contribute to cognitive decline, cerebral atrophy and white matter abnormalities in humans. Adult rat models of streptozotocin-induced DM1 and genetic strains of DM2 and HTN were used to investigate relative contributions of DM and HTN for alterations in cerebral structure and function as well as insulin receptor biology using cognitive testing, magnetic resonance imaging (MRI), and histological and molecular methods. The effects of DM1 or DM2 were generally similar. DM was associated with earlier onset of cognitive impairment than with HTN alone. DM was independently correlated with brain atrophy, whereas HTN had minimal effects on brain volume. The combination of DM and HTN led to identifiable mild hippocampal neuronal loss while either DM or HTN led to synaptic loss. Only DM led to downregulation of the insulin receptor pathways' activation. In contrast, only HTN was associated with vascular luminal reduction and restricted cerebral perfusion on MRI. The impacts of DM and HTN in the brain differ, while their separate contributions can lead to some additive adverse effects within rodent brain grey matter. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：161 / 173

页数：13

共 46 条

[1]

Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese elderly diabetes intervention trial (J-EDIT) [J].