High on-treatment platelet reactivity with ticagrelor versus prasugrel: a systematic review and meta-analysis

被引：53

作者：

Lemesle, G. ^{[1
,2
,3
]}

Schurtz, G. ^{[1
]}

Bauters, C. ^{[1
,2
,3
]}

Hamon, M. ^{[4
,5
]}

机构：

[1] CHRU Lille, F-59037 Lille, France

[2] Inst Pasteur, Inserm U744, F-59019 Lille, France

[3] Univ Lille, Fac Med, Lille, France

[4] Ctr Hosp Univ Caen, Caen, France

[5] Fac Med Caen, Caen, France

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2015年 / 13卷 / 06期

关键词：

acute coronary syndrome; antiplatelet agents; coronary artery disease; percutaneous coronary intervention; platelet function tests; ACUTE CORONARY SYNDROME; ASPIRIN-TREATED PATIENTS; MYOCARDIAL-INFARCTION; RANDOMIZED ASSESSMENT; DOSE CLOPIDOGREL; ACHIEVES GREATER; INHIBITION; INTERVENTION; EVENTS; IMPACT;

D O I：

10.1111/jth.12907

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundTicagrelor and prasugrel have shown superiority over clopidogrel. However, it remains unclear if one is superior to another regarding on-treatment platelet reactivity. ObjectivesTo compare the impact of ticagrelor and prasugrel on high on-treatment platelet reactivity (HTPR). MethodsThe PubMed and Cochrane databases were searched for eligible studies in December 2014. Studies were eligible if they compared ticagrelor and prasugrel regarding high on-treatment platelet reactivity (HTPR). Pooled estimates were calculated by using a random-effects model with 95% confidence intervals. ResultsWe included 14 studies and 1822 patients: 805 and 1017 in the ticagrelor and prasugrel groups, respectively. The rate of HTPR was significantly lower in the ticagrelor group: 1.5% vs. 9.8% (RR=0.27 [0.14-0.50]). The pre-specified analysis focusing on randomized trials (n=10) showed consistent results (RR=0.27 [0.12-0.60]). ConclusionOur results suggest that ticagrelor allows a higher platelet reactivity inhibition as compared with prasugrel and leads to a further decrease in the rate of HTPR.

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页码：931 / 942

页数：12

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