Grey matter correlates of syndromes in schizophrenia - A semi-automated analysis of structural magnetic resonance images

被引:86
作者
Chua, SE
Wright, IC
Poline, JB
Liddle, PF
Murray, RM
Frackowiak, RSJ
Friston, KJ
McGuire, PK
机构
[1] INST PSYCHIAT, LONDON, ENGLAND
[2] CASTLE PEAK HOSP, TUEN MUN, HONG KONG
[3] UCL NATL HOSP NEUROL & NEUROSURG, WELLCOME DEPT COGNIT NEUROL, LONDON WC1N 3BG, ENGLAND
[4] UNIV BRITISH COLUMBIA, VANCOUVER, BC V5Z 1M9, CANADA
基金
英国惠康基金;
关键词
D O I
10.1192/bjp.170.5.406
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Symptoms in schizophrenia cluster into syndromes, each of which may be associated with a particular pattern of cerebral blood flow. We sought to investigate whether these syndromes are also related to neuroanatomical changes. Method A semi-automated method was used to examine structural magnetic resonance images in 12 patients with schizophrenia. The relationship between the relative regional grey matter volume and ratings of the syndromes of psyche motor poverty, disorganisation and reality distortion was investigated. Results There was a significant negative correlation between npsychomo tor poverty score and the relative volume of the left ventro-medial prefrontal grey matter, and a significant positive correlation between disorganisation and the relative volumes of the hippocampus, and the parahippocampal/fusiform gyrus bilaterally. Conclusion The correlation between psychomotor poverty and left prefrontal grey matter volume resembles that previously seen with prefrontal blood flow in the same patients, suggesting that this functional abnormality is related to an underlying anatomical change.
引用
收藏
页码:406 / 410
页数:5
相关论文
共 24 条
  • [1] Andreasen N.C., 1987, COMPREHENSIVE ASSESS
  • [2] [Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th
  • [3] BAILEY DL, 1991, J CEREB BLOOD FLO S2, V11, pS150
  • [4] BERMAN KF, 1992, ARCH GEN PSYCHIAT, V49, P927
  • [5] BROWN R, 1986, ARCH GEN PSYCHIAT, V43, P36
  • [6] CAUDATE NUCLEI VOLUMES IN SCHIZOPHRENIC-PATIENTS TREATED WITH TYPICAL ANTIPSYCHOTICS OR CLOZAPINE
    CHAKOS, MH
    LIEBERMAN, JA
    ALVIR, J
    BILDER, R
    ASHTARI, M
    [J]. LANCET, 1995, 345 (8947): : 456 - 457
  • [7] SCHIZOPHRENIA - A BRAIN DISEASE - A CRITICAL-REVIEW OF STRUCTURAL AND FUNCTIONAL CEREBRAL ABNORMALITY IN THE DISORDER
    CHUA, SE
    MCKENNA, PJ
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 1995, 166 : 563 - 582
  • [8] Neurobiology of schizophrenia
    Deakin, JFW
    [J]. CURRENT OPINION IN PSYCHIATRY, 1996, 9 (01) : 50 - 56
  • [9] Friston Holmes, 1994, Human Brain Mapping, V2, P189, DOI [10.1002/hbm.460020402, DOI 10.1002/HBM.460020402]
  • [10] Friston K., 1995, HUM BRAIN MAP, V2, P165, DOI DOI 10.1002/HBM.460030303