Penetration of meropenem in lung, bronchial mucosa, and pleural tissues

被引：22

作者：

Byl, B

Jacobs, F

Roucloux, I

de Franquen, P

Cappello, M

Thys, JP

机构：

[1] Free Univ Brussels, Hop Erasme, Infect Dis Clin, B-1070 Brussels, Belgium

[2] Free Univ Brussels, Hop Erasme, Dept Thorac Surg, B-1070 Brussels, Belgium

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 03期

关键词：

D O I：

10.1128/AAC.43.3.681

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Lung, bronchial mucosa, and pleural tissue samples were obtained from 14 patients undergoing lung surgery 1 to 5 h after administration of 1 g of meropenem. The mean (range) peak concentrations of meropenem were 3.9 (0.2 to 8.2), 6.6 (3.0 to 13.3), and 2.8 (0.6 to 7.8) mg/kg of tissue, respectively, exceeding the MICs at which 90% of isolates are inhibited for most respiratory pathogens.

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页码：681 / 682

页数：2

相关论文

共 14 条

[1] PROPHYLACTIC AND THERAPEUTIC ACTIVITIES OF AZITHROMYCIN IN A MOUSE MODEL OF PNEUMOCOCCAL PNEUMONIA [J].

AZOULAYDUPUIS, E ;

VALLEE, E ;

BEDOS, JP ;

MUFFATJOLY, M ;

POCIDALO, JJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (06) :1024-1028

[2] ANTIPNEUMOCOCCAL ACTIVITY OF CIPROFLOXACIN, OFLOXACIN, AND TEMAFLOXACIN IN AN EXPERIMENTAL MOUSE PNEUMONIA MODEL AT VARIOUS STAGES OF THE DISEASE [J].

AZOULAYDUPUIS, E ;

BEDOS, JP ;

VALLEE, E ;

HARDY, DJ ;

SWANSON, RN ;

POCIDALO, JJ .

JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (02) :319-324

[3] PULMONARY DISPOSITION OF ANTIMICROBIAL AGENTS - INVIVO OBSERVATIONS AND CLINICAL RELEVANCE [J].

BALDWIN, DR ;

HONEYBOURNE, D ;

WISE, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (06) :1176-1180

[4] IMIPENEM KINETICS IN SERUM, LUNG-TISSUE AND PERICARDIAL FLUID IN PATIENTS UNDERGOING THORACOTOMY [J].

BENONI, G ;

CUZZOLIN, L ;

BERTRAND, C ;

PUCHETTI, V ;

VELO, G .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1987, 20 (05) :725-728

[5] PREDICTING THE EFFICACY OF ANTIMICROBIAL AGENTS IN RESPIRATORY-INFECTIONS - IS TISSUE CONCENTRATION A VALID MEASURE [J].

BERGOGNEBEREZIN, E .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1995, 35 (03) :363-371

[6] THERAPEUTIC EFFICACY OF CEFADROXIL AND CEPHALEXIN FOR PNEUMONIA IN A RAT TEST MODEL [J].

CHISHOLM, DR ;

DEREGIS, RG ;

BEHR, DA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (01) :105-109

[7] AZITHROMYCIN (CP-62,993) IN ACUTE EXACERBATIONS OF CHRONIC-BRONCHITIS - AN OPEN CLINICAL, MICROBIOLOGICAL AND PHARMACOKINETIC STUDY [J].

DAVIES, BI ;

MAESEN, FPV ;

GUBBELMANS, R .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1989, 23 (05) :743-751

[8]

DRUSANO GL, 1995, SCAND J INFECT DIS, P11

[9]

EDWARDS JR, 1995, J ANTIMICROB CHEMOTH, V36, P1

[10] A COMPARISON OF THE PHARMACOKINETICS OF MEROPENEM AFTER ADMINISTRATION BY INTRAVENOUS-INJECTION OVER 5 MINUTES AND INTRAVENOUS-INFUSION OVER 30 MINUTES [J].

KELLY, HC ;

HUTCHISON, M ;

HAWORTH, SJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1995, 36 :35-41